The short answer is no.
The long answer is that Macs don’t have a registry since macOS is based on FreeBSD, an operating system that is very different from Windows OSs. Hence why most Mac cleaners focus on deleting cache files, unused programs, hoarded junk data, logs and many more.
However, there are plenty of other features that can be found in both PC and Mac optimization software, such as file shredder, deep (and scheduled) scans, a program uninstaller, add-on manager and a startup optimizer that turns off as many programs as you want to speed up the startup process. Some solutions are also capable of optimizing your computer’s memory and grant safer web browsing by wiping your internet history and cookies clean, and even provide antivirus and antimalware features.
More advanced software will take care of the automatic updates of other programs, restore files that were once deemed deleted, create backups for you, and can even monitor your computer for junk files in real-time so you are able to take countermeasures when necessary. Sometimes there is even the option to use a remote desktop function, whereby a trained technician takes control of your device (under your supervision, of course) to deal with the cleanup for you – which is a huge asset for less tech-savvy users.
Unfortunately, there are very few companies that actually develop the same (or at least similar) optimization products for PCs and Macs. In fact, Mac products are usually inferior compared to PC registry cleaners due to the fact that they include fewer features. Not to mention the fact that the overall better reliability of Macs and a greater versatility of built-in junk removal options means there is less demand for software to deal with this problem. While the Mac userbase is growing and Apple is eating away market share from Windows, the number of Mac users is still far below that of the PC, which makes it more tempting for software developers to create software for the Windows ecosystem.
Out of the many Mac optimizers we have tested there is one case where the Mac version is better than its PC counterpart: MacPaw’s CleanMyMac. While the PC version CleanMyPC is almost equally good, the Mac software is the most complete solution MacPaw has in store. Piriform on the other hand first came out with the PC version of their CCleaner software, and later on Mac users got to enjoy the software for their operating system of choice as well. While CCleaner is a well-rounded solution, it’s not on par with the PC version just yet.